Studies on Gastrointestinal Hormones

Structural Studies on Polypeptide Hormones

The structures of three polypeptide hormones (glucagon, a 25-residue analogue of adrenocorticotropin, and parathyroid hormone) which contain enough residues to permit organization have been evaluated in aqueous solution by fluorescence and circular dichroism. The effects of pH, temperature, and guanidine on both tyrosyl and tryptophanyl emission have been measured. None of the fluorescence para...

Gut hormones in gastrointestinal disease.

Considerable advances have been made in the understanding of the physiology of gut hormones. Thus, knowledge of the mechanisms of release and of the actions of many of the hormones is rapidly expanding. The known clinical importance of gut hormones is at present confined only to the excess production of gastrin, VIP, and pancreatic glucagon by endocrine tumours. The role of these three and the ...

Gastrointestinal Hormones: Introduction and Index

[Effect of the gastrointestinal hormones on insulin secretion].

概 要 Secretin, pancreozyminお よびgastrinに よるinsulin分泌刺激作用 を,麻 酔犬 の門脈血 お よび末梢 血,正 常 人,糖 尿病患者 の末梢 血 で観察 した.三 者 ともに,insulinはDILA, FILA, IRIと も注射後1分 ない し3分 にpeakに 達 し, 10分 には速やか に下 降 し, 30分 には前 値 に復 した。 この間 血 糖 は無 変化で あつた.糖 尿病患 者では分泌像 は正常 人 と同様 であ るが,分 泌の低 下が み られ た.消 化 管 ホル モ ンに よる急激で しか も一過 性 のinsulin分泌は血糖 を介せず に行 な われ ていて,食 物摂 取時, 未 だ血糖 の上 昇 しない時, insulin分泌 をお こさせ,一 時 的 にせ よ血糖が無 制限に上昇 す るのを防 ご う とす...

Chemistry, isolation and purification of gastrointestinal hormones.

The isolation in the early 1960s (Gregory & Tracy, 1975; Jorpes & Mutt, 1973) from porcine intestinal and gastric antral tissues of the classical gastrointestinal hormones gastrin, secretin and cholecystokinin, the latter having also the properties ascribed to pancreozymin, confirmed the long-suspected peptide nature of these substances. It then seemed-for a time-that the field of gastrointesti...